Anti Aging

Does NMN Make You Look Younger?

Does NMN Make You Look Younger?

In the quest for eternal youth, the spotlight often lands on groundbreaking supplements with the promise of reversing the signs of aging. One such compound that has captured the imagination of scientists and the public alike is Nicotinamide Mononucleotide (NMN).


As discussions swirl around its potential anti-aging benefits, a critical question emerges: Does NMN make you look younger? This article delves into the scientific understanding of NMN, its effects on aging, and what current research tells us about its potential to rejuvenate our appearance.


Understanding NMN


NMN is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital molecule in energy production, DNA repair, and cell signalling. NAD+ levels naturally decline as we age, leading to a decrease in cellular function and the onset of age-related physiological changes. 


By supplementing with NMN, it's theorised that we can boost NAD+ levels, thereby supporting cellular health and potentially slowing down aspects of the aging process (R).


The Science of NMN and Aging


The connection between NMN and anti-aging stems from its capacity to increase NAD+ levels, thus enhancing energy metabolism, promoting DNA repair, and supporting the activity of sirtuins—proteins associated with longevity (R). 


Animal studies have shown promising results, including improved energy metabolism, enhanced physical performance, and decreased age-related biomarkers (R). However, the leap from these findings to visible anti-aging effects, such as reduced wrinkles or improved skin elasticity, requires a closer examination of the evidence.


NMN Skin Benefits

Does NMN Make You Look Younger?


Research on NMN and its impact on skin health, particularly concerning aging and UV-induced skin damage, has provided promising insights.


One study highlighted the effects of NMN combined with Lactobacillus fermentum TKSN041 on murine skin exposed to UVB radiation. The study found that this combination significantly increased antioxidant enzymes, reduced inflammatory cytokines, and activated the AMPK signalling pathway, crucial for cellular energy homeostasis and longevity. 


The treatment improved skin damage caused by UVB irradiation, suggesting a protective mechanism related to activating the AMPK signalling pathway (R).


Another investigation into the administration of NMN via intraperitoneal injection in mice exposed to UVB showed that NMN treatment maintained normal skin and liver morphology, enhanced antioxidant capacity, regulated proinflammatory responses, and promoted the activation of the AMP-activated protein kinase (AMPK) signalling pathway in skin and liver. 


These findings suggest that NMN can block photodamage caused by UVB irradiation by regulating oxidative stress and inflammatory responses, highlighting its potential in skin health and aging prevention (R).


These studies indicate that NMN has a significant potential to improve skin health, particularly in reducing the damage caused by UV radiation, one of the important factors contributing to skin aging. 


The activation of the AMPK signalling pathway and the enhancement of the skin's antioxidant capacity by NMN could be pivotal mechanisms through which NMN exerts its protective effects against skin aging and damage.


Human Studies and Real-world Effects


While animal research provides a foundation for understanding NMN's potential, human studies are crucial in determining its efficacy in making individuals look younger. Early clinical trials have begun to explore the impact of NMN on various age-related parameters, including skin health (R). 


Although these studies are promising, more extensive research is needed to prove NMN's anti-aging effects on human appearance.


NMN as Part of a Holistic Anti-Aging Strategy


It's important to note that while potentially beneficial, NMN is not a miracle solution for aging. Experts agree that a holistic approach encompassing a balanced diet, regular exercise, adequate sleep, and proper skincare practices is essential for maintaining youthful appearance and health. 


NMN may complement these lifestyle factors, potentially enhancing their effectiveness in slowing the aging process.




The question of the potential that NMN has for making you look younger is met with optimism in the scientific community. However, there is still much to learn. Preliminary evidence suggests potential benefits for skin health and overall cellular vitality. 

For those considering NMN as part of their anti-aging regimen, viewing it as one piece of a larger puzzle is crucial, emphasising the importance of a healthy lifestyle alongside supplements like AgeMate NMN.

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Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

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