NAD+ levels decline with age, and this has been linked to age-related diseases such as Alzheimer's and Parkinson's (see references below). Supplementing with NAD+ precursors such as NMN has been shown to boost NAD+ levels and reverse some of the signs of aging in animal studies.
If NAD+ supplements are proven to be effective over the long run, they could have a profound impact on public health, potentially extending life expectancy and reducing the burden of age-related diseases.
How does NAD+ work in the body?
NAD+ is a molecule that's found in every cell of your body. It's involved in a wide range of metabolic processes, and it plays an important role in energy production, DNA repair, and aging. NAD+ levels decline with age, which can lead to age-related diseases.
Studies have shown that boosting NAD+ levels can improve health and longevity. NAD+ supplements are available, but they're expensive and not very effective.
A better option is to take NMN or NR, an NAD+ precursor that's easily absorbed by the body. NMN has been shown to increase NAD+ levels and protect against age-related diseases in animal studies. human studies are ongoing, but early results are promising.
If you're looking for ways to live healthier and longer, NAD+, NMN or NR supplementation is a promising option worth considering.
NAD+ levels drop with aging
The human body is an amazing machine that can adapt and change in response to its environment. But one thing that it can't do is stop the hands of time. As we age, our cells experience more DNA damage, and our NAD+ levels start to decline.
This Decline in NAD+ has been linked to a number of age-related diseases, such as diabetes, cancer, and Alzheimer's disease. While there's no way to completely stop the aging process, there are things we can do to slow it down.
For example, exercising and eating a healthy diet can help keep our cells healthy and prevent some of the DNA damage that occurs with age.
So even though we can't turn back the clock, we can take steps to protect our cells and prolong our healthspan.
How is NAD+ made by our cells?
NAD+ is produced by our cells as part of our metabolism. In order to make NAD+, cells use a process called the NAD salvage pathway. This pathway involves taking NADH that has been used by the cell and recycling it back into NAD+.
NADH is recycled back into NAD+ through a series of reactions that involve enzymes. These reactions convert NADH back into NAD+, which can then be used again by the cell.
The NAD salvage pathway is an important part of metabolism, and it helps to keep NAD+ levels high so that cells can function properly.
What is NAD+ made of?
NAD+ is an important molecule in the body that is made up of two nucleotides joined together by phosphate groups.
One nucleotide contains an adenine nucleobase and the other contains a nicotinamide.
NAD+ is important for many cellular processes, including DNA repair, energy metabolism, and cell signaling. NAD+ levels decline with age, and this has been linked to age-related diseases such as Alzheimer's disease, cancer, and Type II diabetes.
However, NMN supplementation has been shown to reverse some of the age-related changes in NAD+ levels and improve health in animal studies.
What happens when NAD+ levels are reduced?
Numerous studies have shown that NAD+ levels are reduced in conditions of disturbed nutrient intake, such as obesity and aging.
This reduction in NAD+ can lead to problems with metabolism, which can, in turn, lead to disorders such as obesity and insulin resistance.
Obesity is a major risk factor for diabetes and high blood pressure. Therefore, maintaining healthy NAD+ levels is crucial for preventing these serious health problems.
Not to mention that reduced NAD+ levels can also lead to lower strength, older looking skin, decreased eye sight and many other factors that come with the aging process.
NAD+ is important for mitochondrial maintenance and gene regulation, both of which are crucial for preventing aging. However, NAD+ levels in our body drastically decline as we age.
"By the time you're 50, you have about half the NAD+ you once had when you were 20," says David Sinclair of Harvard University. This decrease in NAD+ results in a decrease in mitochondrial function and an increased risk for age-related diseases. However, there are ways to counteract this NAD+ loss.
Exercise and caloric restriction have been shown to increase NAD+ levels, as well as raise levels of SIRT1, an anti-aging protein. Additionally, supplements that contain NAD precursors, such as nicotinamide riboside (NR), can also raise NAD+ levels.
By maintaining high NAD+ levels, we can keep our mitochondria healthy and avoid age-related diseases.
The sirtuin family of genes are some of the most important genes in the body. Often referred to as the "guardians of the genome," sirtuins play a vital role in maintaining the health of cells and preventing disease.
Sirtuins are responsible for sensing when the body is under stress, such as during exercise or periods of starvation, and sending out troops to defend the body.
In addition to their role in protecting the genome, sirtuins also promote DNA repair and have been shown to have anti-aging properties in model animals.
Thus, sirtuins play a critical role in maintaining the health of the body and preventing age-related diseases.
Mitochondria are often referred to as the powerhouse of the cell, and for good reason. These organelles are responsible for producing the energy our cells need to function. NAD+ is a key player in mitochondrial function, and research has shown that it plays an important role in exercise performance.
NAD+ levels decline with age, and this can lead to decreased muscle function. However, supplementing with NAD+ can help to restore mitochondrial function and improve exercise performance.
In one study, participants who supplemented with NAD+ saw a significant increase in endurance compared to those who didn’t supplement.
So if you’re looking to maintain healthy mitochondria and steady energy output, NAD+ may be worth considering.
Obesity is a condition that is characterized by an excessive amount of body fat. Obesity can lead to a number of health problems, including metabolic disorders such as diabetes. In 2016, diabetes killed 1.6 million people around the globe.
Obesity is also a risk factor for heart disease and stroke. In fact, obese individuals are more likely to die from heart disease than non-obese individuals.
Treatment for obesity often includes lifestyle changes such as diet and exercise. Medications and surgery may also be used in severe cases.
If you are obese, it is important to talk to your doctor about treatment options.
The heart is a vital organ that pumps blood throughout the body. The arteries are responsible for carrying blood away from the heart.
The elasticity of the arteries helps to cushion the pressure waves sent out by heartbeats. However, as we age, our arteries begin to stiffen and this can contribute to high blood pressure.
High blood pressure is one of the most important risk factors for cardiovascular disease.
Cardiovascular disease is the leading cause of death in the United States, with one person dying from it every 37 seconds. The CDC reports that almost half of all adults in the United States have some form of cardiovascular disease.
Heart health is therefore a key concern for many people. By maintaining a healthy lifestyle and getting regular check-ups, we can help to reduce our risk of developing cardiovascular disease.
Neurodegeneration is a major problem facing the world today. Neurodegenerative diseases are characterized by the progressive loss of structure and function of neurons, resulting in cognitive impairment. The most common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
These diseases are devastating, not only for the individuals affected, but also for their families and caregivers. Neurodegenerative diseases are currently incurable, and there is no effective way to prevent or slow their progression.
However, research is ongoing, and scientists are hopeful that new treatments will be developed to improve the quality of life for those affected by neurodegenerative diseases.
Does NAD+ increase lifespan?
If you're a mouse, then yes, taking NAD+ precursors can help you live a longer and healthier life. That's what scientists have found in a study published in Science in 2016. In the study, mice that were given NR, a precursor to NAD+, lived an average of 5% longer than mice that didn't receive NR.
The mice receiving NR also showed signs of improved healthspan, meaning they spent more of their lives free of age-related diseases.
So if you're looking for ways to extend your lifespan and improve your healthspan, boosting your NAD+ levels may be a good place to start.
How to Increase NAD Levels
NAD+ levels can be naturally increased by promoting its synthesis — enhancing the enzymes involved in NAD+ biosynthesis or taking NAD+ precursor molecules.
Eating healthy and exercising regularly are two of the best things you can do for your mental health. But did you know that these activities can also help to boost your NAD+ levels? NAD+ is a molecule that plays an important role in energy metabolism, and levels of this molecule decline with age.
However, mild physical stress to the body such as fasting and exercise can stimulate the production of NAD+.
As a result, leading a healthy lifestyle through a healthy diet and moderate exercise is not only good for your mental health, but it can also help to keep your NAD+ levels high.
Moving Your Body
Regular exercise is one of the simplest ways to improve your overall health and increase your NAD+ levels. Exercise helps to keep you strong and fit, whilst also maintaining a healthy weight.
In addition, exercise can enhance the DNA-rebuilding proteins in your body, helping to keep your cells healthy and prevent disease.
So if you're looking for a natural way to improve your health, be sure to get plenty of exercise. Your body will thank you for it!
Staying out of the sun’s harmful rays
levels of NAD+ decline with age, and this has been linked to a number of age-related diseases. However, new research suggests that exposure to sunlight may also play a role in reducing NAD+ levels.
UV radiation from the sun causes damage to the skin, and the body uses NAD+ to repair this damage. As a result, spending too much time in the sun can lead to a significant decrease in NAD+ levels.
This is yet another reason to make sure you wear sunscreen and limit your exposure to direct sunlight.
Searching for heat sources
While spending time in direct sunlight is bad for your overall health and NAD+ levels, spending time in natural or artificial heat can certainly help you boost those NAD levels.
Common heat sources, such as saunas, hot tubs, and heated pools may cause your heart to beat quicker, forcing your body to use more energy to keep cool. This increase in energy expenditure leads to an increase in NAD+ levels.
So, if you're looking for a way to boost your NAD+ levels, spending some time in the heat may be a good option for you.
Supplementing with NAD+ precursors
Both NMN and NR are used in the "salvage pathway" of NAD+ biosynthesis. This means that they can be converted into NAD+ in the body, boosting levels of this important molecule.
In addition, both NMN and NR are safe for human consumption. As a result, they offer a potential way to increase NAD+ levels and slow down age-related declines in cellular function.
Why do people take NAD+?
Some people take NAD+ supplements in an attempt to slow the aging process. Additionally, NAD+ has been shown to boost energy levels and improve exercise performance. In fact, one study found that NAD+ supplements enhanced muscle function in older adults (1).
Additionally, NAD+ is also involved in the production of collagen and elastin, two proteins that are essential for maintaining youthful skin (2).
Finally, NAD+ supplements have been shown to protect against age-related diseases such as Alzheimer’s and Parkinson’s (3).
While NAD+ supplements show promise, it’s important to remember that more research is needed to confirm their efficacy.
The Future of NAD+
As the population continues to age, chronic diseases will become an increasingly burdensome issue. In 2016, the nation's health care treatment for chronic diseases totaled $1.1 trillion, according to the Milken Institute.
A large portion of this cost is due to the treatments for Alzheimer's and dementia, which are projected to increase five-fold by 2050. However, there may be hope on the horizon in the form of NAD+. NAD+ is a molecule that plays a role in cell metabolism, and it has been shown to decrease with age.
Recent research has suggested that boosting levels of NAD+ could potentially reverse some of the damages associated with aging, including cognitive decline. While more research is needed, the potential of NAD+ offers a ray of hope for those facing the challenges of an aging population.