Dr. David Sinclair is a world-renowned expert on the science of aging, and he has made a habit of taking various supplements to help slow the aging process.
Some of the supplements Dr. Sinclair takes include resveratrol, pterostilbene, nicotinamide mononucleotide (NMN), and quercetin.
He believes that these supplements work together to help his body produce more energy, repair damaged DNA, and protect cells from stress.
In addition, Dr. Sinclair also takes fish oil and vitamin D3 to support cognitive health and maintain a healthy immune system.
While there is no magic pill that can completely stop the aging process, taking these supplements appears to be helping Dr. Sinclair stay young and healthy well into his older years.
Nicotinamide mononucleotide (NMN): 1g per day, in the morning
NMN has been shown to have many anti-aging benefits in animal studies, including DNA protection and repair, epigenome regulation, and metabolism regulation.
NMN is a precursor to NAD+, which is an important molecule for many cellular processes. Studies have shown that high doses of NMN (1000 mg) are effective for these benefits, but lower doses (250-500 mg) are also effective.
David Sinclair, a leading researcher in the field of aging, takes NMN regularly as part of his longevity regimen. NMN is a promising supplement for those interested in living a long and healthy life.
He's also been quoted as taking nmn at night
Resveratrol: 1g per day, in the morning
Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Studies have shown that resveratrol can reduce the risk of heart disease, cancer and neurodegeneration.
David Sinclair, a scientist at Harvard Medical School, believes that resveratrol works synergistically with NMN (nicotinamide mononucleotide). Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins.
However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. Dr. Sinclair has been working on developing a way to deliver resveratrol more effectively to the body so that it can reap the maximum benefits of this powerful compound. More to come on this soon...
Metformin: 800 mg, in the evening
Metformin is a medication that has been shown to extend lifespan in various organisms, including mammals. In humans, we see that diabetics taking metformin actually live longer than healthy non-diabetics who obviously don’t take metformin.
This was not the case for diabetics on other anti-diabetic drugs. Taking metformin can, however, have side effects. In the short-term, metformin can cause diarrhea and gastrointestinal discomfort, which often subsides after a few weeks. In the long-term, metformin can reduce the uptake of vitamin B12.
Metformin probably works as a hormetic substance, meaning that it causes a little bit of damage to our cells so that our cells are put in a repair and protect modus. Metformin inhibits mitochondrial function, so the mitochondria will repair and protect themselves better.
Vitamin D3: ideally 4000 to 5000 IU per day
Vitamin D is a nutrient that has many benefits for health. One of these benefits is that it can help to extend lifespan.
This has been shown in studies with simple organisms, and it is thought that vitamin D could also have a similar effect in humans. Vitamin D may also reduce the risk of various aging-related diseases, such as heart disease, type 2 diabetes, autoimmune diseases and Alzheimer’s disease.
This is because vitamin D activates many genes that confer important health benefits. Therefore, ensuring adequate vitamin D intake may be a key component of healthy aging.
Vitamin K2: ideally 180 to 360 microgram per day
Most people know that vitamin K is important for bone health, but what they may not realize is that it's also crucial for vascular and mitochondrial health.
Vitamin K also happens to be great for your skin, helping to improve its appearance. If you're taking vitamin D, it's best to also take vitamin K2 (MK-7 is the best form) since the two vitamins work synergistically.
However, it's important to remember that taking just a few vitamins isn't enough: most people are deficient in many other vitamins, minerals and micronutrients even when they eat healthy.
So make sure you're getting all the nutrients you need for optimal health!
Statin - Prescription Drug
Since this a prescription drug for cardiovascular disease we're not going to go into details on this.
Low-dose aspirin: 83 mg per day
Although aspirin has been shown to have a variety of health benefits, a recent large-scale study has cast doubt on its effectiveness. The study, which involved almost 20,000 participants and lasted 4.7 years, showed that a low dose of aspirin did not reduce cardiovascular disease or improve survival.
In fact, the study even showed that aspirin could actually increase cancer risk somewhat, despite many other studies showing that aspirin could have health and longevity benefits.
However, the large-scale nature of the study means that its findings should be taken with a grain of salt. Aspirin still has the potential to reduce inflammation, reduce the risk of heart attacks, and perhaps even the risk of cancer.
Alpha lipoic acid (ALA): recent status unknown
Alpha lipoic acid is a strong antioxidant. There has been a bit of a hype around ALA, especially combined with acetyl-L-carnitine (ALCAR), to slow down aging. However, there are various studies showing that ALA does not extend lifespan or slow down aging.
However, alpha lipoic acid is a strong antioxidant, and scientists have learned that antioxidants could actually accelerate aging (as we explain here). So we should not be surprised to see that in studies in which aging mice receive alpha lipoic acid their lifespans are actually shortened.
Despite the fact that alpha lipoic acid might speed up the aging process, it is still a powerful antioxidant that can offer many health benefits. So if you are looking for an antioxidant supplement, ALA might be a good option. But don't expect it to help you live longer!
Coenzyme Q10 (coQ10): recent status unknown
Coenzyme Q10 is an antioxidant that occurs naturally in the body. It is found in every cell, where it helps to produce energy and protect cells from damage. Some people take supplements of coenzyme Q10 in the hopes that it will improve mitochondrial function and extend their lifespan.
However, there is insufficient scientific evidence to support these claims. Various studies have shown that, at best, coenzyme Q10 has no effect on lifespan. In some cases, it may even shorten lifespan.
Therefore, people should be cautious about taking supplements of this nutrient without first consulting a doctor.
OTHER THINGS DAVID SINCLAIR DOES TO LIVE LONGER
His research has led him to develop some interesting eating habits. Rather than eating three meals a day, Sinclair often sticks to just two.
And rather than snacking throughout the day, he often goes for long periods without eating anything at all.
Despite these fasting periods, Sinclair still gets plenty of energy from his food. He regularly drinks green tea, which is packed with antioxidants and other nutrients that can boost energy levels.
And he makes sure to eat plenty of vegetables, which are packed with fiber and other nutrients that help the body function efficiently.
By following these simple dietary guidelines, Sinclair has been able to stay healthy and productive well into his later years.
David Sinclair is a firm believer in the benefits of exercise, and he's made it a priority in his life. He runs once or twice a week, alternating between low-intensity and high-intensity workouts.
He also weight lifts once or twice a week. This commitment to fitness has paid off for him in countless ways. He has more energy, he sleeps better, and his overall health is much better.
Plus, he credits exercise with helping him to maintain his mental sharpness as he gets older. Exercise is clearly a key part of David Sinclair's success formula, and it's something that he recommends to others as well.
David Sinclair clearly knows what he's talking about when it comes to supplements as he's considered one of the top scientists in the world when it comes to aging.
He openly admits that some things he does today will be wrong but he openly discusses them and follows the science.
His top recommendation as heard on the Joe Rogan podcast has been for people to start taking NMN Supplements when they hit their 30s.
Despite his list of recommended supplements he admits that there is no substitute for a healthy diet (specifically not eating too much) and exercise as these are still important factors in his life.