Thiamine HCI (Vitamin B1)

Thiamine HCI (Vitamin B1)


  • Thiamine HCl is a stable, water-soluble form of Vitamin B1, essential for energy production and glucose metabolism.
  • It's effectively absorbed, which is crucial for those at risk of deficiency.
  • Linked to lower risk of coronary artery disease by reducing homocysteine levels.
  • Essential for preventing oxidative stress-related aging diseases and supports cognitive health.
  • Supplementation can improve quality of life, reduce blood pressure, and aid in weight management.
  • May activate defence mechanisms, indicating a potential role in enhancing longevity.
  • Involved in metabolic processes, suggesting its importance in cellular health.
  • Adequate intake is vital for preventing mitochondrial dysfunction and chronic diseases.
  • Thiamine HCl is key for converting carbs to energy and is preferred in supplements for its solubility and stability, essential for preventing deficiency and supporting overall health.

What is Thiamine HCI (Vitamin B1)?


Thiamine HCl, the hydrochloride salt of Thiamine (Vitamin B1), is a water-soluble vitamin essential for converting carbohydrates into energy, crucial for the metabolism of glucose. It's widely used in dietary supplements and medications due to its enhanced stability and water solubility (R). 


Thiamine HCl is absorbed well by the body, ensuring an effective way to meet the daily intake requirements of this important vitamin, especially in individuals at risk of deficiency.


Thiamine HCI (Vitamin B1) Impact on Aging


Thiamine deficiency is linked with elevated plasma total homocysteine concentrations, which are associated with an increased risk for certain diseases such as coronary artery disease. Older adults may have a high prevalence of low B vitamin status, including thiamine, and elevated plasma homocysteine concentration (R).


Thiamine deficiency in mice produces fibre cell degeneration in mouse lenses, indicating that thiamine is critical in preventing oxidative stress-related degeneration. Maintaining adequate thiamine levels may help prevent or slow down age-related degenerative diseases (R).


Subclinical thiamine deficiency in older adults is improved with thiamine supplementation, leading to subjective benefits such as improved quality of life and decreased systolic blood pressure and weight. This implies that even mild thiamine deficiency can affect the health and well-being of older adults, and supplementation can have positive effects (R).


Thiamine deficiency (TD) has been shown to cause long-lasting neurobehavioral deficits in mice, suggesting that even temporary thiamine deficiency can have prolonged effects on behaviour and cognitive function. This underscores the importance of maintaining adequate thiamine levels for cognitive health, particularly in aging populations (R).


Thiamine HCI (Vitamin B1) and Longevity Studies


Interestingly, thiamine has been shown to induce systemic acquired resistance (SAR) in plants against fungal, bacterial, and viral infections. While this effect is in plants, it highlights thiamine's potential role in activating defence mechanisms that might have parallels in animal systems and an impact on longevity (R).


Beyond its coenzyme role, thiamine and its derivatives have been implicated in the allosteric regulation of several enzymes involved in energy metabolism, suggesting a complex role in cellular and metabolic processes that could indirectly influence longevity (R).

Reading next

Vitamin B6 (Pyridoxine HCI and Pyridoxal 5'-Phosphate)
Vitamin B12 as Methylcobalamin

Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

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