Key Takeaways:
- NAD+ levels naturally decline with age, leading to reduced energy, slower metabolism, and ageing-related diseases. Supplementation can help restore these levels.
- NMN and NR are the most researched NAD+ precursors.
- Choosing the best NAD+ supplement depends on factors like bioavailability, product quality, and the inclusion of synergistic nutrients like resveratrol.
NAD+ (nicotinamide adenine dinucleotide)—the molecule responsible for energy production and DNA repair—declines by up to 50% by the time you’re in your 40s. Often referred to as the “fuel of life,” NAD+ supports metabolism, brain function, and muscle repair.
Restoring NAD+ levels through supplementation is an exciting strategy for slowing ageing and enhancing vitality. But with so many options available, how do you choose the best NAD+ supplement? Let’s explore the science behind NAD+ and how to find the most effective product for your needs.
Why is NAD+ Important for Healthy Ageing?
NAD+ is a coenzyme found in every cell, playing a critical role in energy production and cellular repair. It drives essential processes such as:
- DNA repair
- Inflammation control
- Mitochondrial health
As NAD+ levels decline with age, symptoms such as fatigue, cognitive decline, and increased risk of chronic diseases like diabetes and heart disease can arise. Restoring NAD+ levels has been shown to improve metabolic health, enhance cognitive function, and even slow certain markers of ageing (R).
How Do NAD+ Supplements Work?
NAD+ supplements often contain precursors—molecules your body converts into NAD+. The two most researched precursors are nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Both work by supporting the salvage pathway, the primary method your body uses to recycle NAD+ from existing molecules (R).
While NAD+ itself isn’t easily absorbed, NMN and NR are highly bioavailable and effective at raising NAD+ levels. Understanding the differences between these two precursors can help you choose the right supplement (R).
NMN vs NR: Which is the Best NAD+ Precursor?
NMN
NMN is a direct precursor to NAD+, meaning your body rapidly converts it into NAD+ in a single step. This makes it one of the most efficient ways to boost NAD+ levels.
Benefits of NMN include:
- Improved endurance and mitochondrial function
- Enhanced muscle repair and reduced inflammation
- Support for vascular health and cognitive function
NMN’s rapid absorption, via specific transporters in the small intestine, adds to its effectiveness (R).
NR
NR, another well-studied precursor, must first be converted into NMN before raising NAD+ levels. Despite this extra step, it’s highly effective and offers unique benefits:
- Improved metabolic health and reduced oxidative stress
- Support for brain function and reduced risk of neurodegenerative diseases
NR has also been studied for its potential benefits in conditions like diabetes and fatty liver disease (R).
Key Factors to Consider When Choosing an NAD+ Supplement
Bioavailability
The best NAD+ supplements are those your body can absorb and use effectively. NMN’s direct conversion pathway gives it a slight edge, although NR's rapid absorption improves effectiveness.
Synergistic Ingredients
Look for supplements that include additional ingredients like resveratrol, which works with NAD+ to activate sirtuins—proteins involved in DNA repair and cellular health.
Quality and Purity
Choose supplements with third-party testing to ensure high purity and no unnecessary fillers or additives. AgeMate supplements are 3rd party tested.
The Role of Synergistic Nutrients in Boosting NAD+
Combining NAD+ precursors with other longevity nutrients enhances their effectiveness:
- Resveratrol: Activates sirtuins and boosts mitochondrial health, amplifying the effects of NMN and NR (R).
- TMG (Trimethylglycine): Supports methylation, which helps recycle NAD+ and maintain cellular health (R).
- Berberine: Enhances cellular energy production by activating AMPK, complementing NAD+ in improving metabolic health (R).
- Spermidine: Promotes autophagy, recycling damaged cells and complementing NAD+ in slowing ageing (R).
What Does the Research Say?
Research shows that both NMN and NR effectively raise NAD+ levels and improve markers of ageing. For example:
- NMN improves insulin sensitivity, physical performance, and mitochondrial function in older adults (R).
- NR enhances cognitive function and reduces inflammation in individuals with mild cognitive impairment (R).
Emerging studies suggest combining NAD+ supplementation with lifestyle interventions like exercise and diet can further maximise benefits.
Tips for Maximising the Benefits of NAD+ Supplements
Choose a Quality Product: Opt for trusted brands with high bioavailability and third-party testing.
Pair with Longevity Nutrients: Combine NMN or NR with resveratrol, TMG, or spermidine for enhanced effects.
Incorporate Lifestyle Changes: Regular exercise, a balanced diet, and stress management amplify the benefits of NAD+ supplements.
Monitor Your Progress: Test your NAD+ levels to track how your body responds to supplementation.
Restoring your NAD+ levels can be a game-changer for healthy ageing and vitality. Whether you choose NMN or NR, prioritising quality and combining it with synergistic nutrients like resveratrol and TMG can enhance your results.
Ready to explore more about supplements for healthy ageing? Check out our blog on: What is an NMN Supplement?
