Anti Aging

NMN Side Effects

NMN Side Effects

NMN is known for its anti-aging benefits and has shown promise in various aspects of health, such as metabolic health, brain function, and muscle strength. However, it's also important to be aware of the potential side effects and the proper dosage to ensure safe usage.


Potential Side Effects and Interactions


As with all supplements, you should approach with caution if you are taking medications or other supplements or have preexisting health conditions. Consulting a health practitioner is advisable. Here are some known side effects and interactions that should be considered.


Consider Dosage

In clinical trials, a Japanese human study revealed that doses of up to 500mg of NMN showed no adverse effects (R), while an endurance study showed no issues at dosages of up to 1200mg (R). Although NMN is generally considered safe and well-tolerated in human studies, doses ranging from 100 to 1200 mg daily show no significant adverse effects. 



Individuals with diabetes should be cautious. NMN has been shown to improve insulin sensitivity, which could alter the effectiveness of anti-diabetic medications, requiring close monitoring and consultation with healthcare professionals (R).


Gastrointestinal Issues

Studies suggest that NMN can positively impact the digestive tract and side effects are rare (R, R). Although some people may experience digestive issues like nausea, vomiting, diarrhoea, or stomach upset when taking NMN.



Some people may experience headaches as a side effect of NMN supplementation. It is possible that headaches could be a side effect for some individuals due to individual differences in metabolism, underlying health conditions, or interactions with other medications or supplements.


Allergic Reactions

In rare cases, some people may be allergic to NMN and experience symptoms like rash, hives, or difficulty breathing.


Interactions with Medications

NMN may interact with certain medications, including blood pressure. If you are concerned, you should always consult your medical practitioner before taking it.


Long-Term Usage


Studies have shown benefits such as weight management and improved insulin sensitivity without obvious toxicity. Still, high-dose nicotinamide (a form related to NMN) has raised concerns regarding carcinogenesis and other health issues (R). 


It's crucial to differentiate between high-dose nicotinamide and NMN; however, long-term research on NMN specifically is still needed.


Health Benefits


While the side effects, as with all supplements, are a concern, NMN has been associated with several health benefits, including enhancing aerobic capacity, boosting insulin sensitivity, improving cardiovascular health, and potentially increasing health span. These benefits highlight NMN's potential role in supporting longevity and metabolic health.




In conclusion, while NMN offers promising benefits, it's important to approach its use cautiously, particularly regarding interactions with medications. 


To ensure safety and effectiveness, it is advisable to consult with a healthcare professional before starting NMN supplementation, especially for individuals with existing health conditions or those taking medications.

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    Written By Natasha Jordan

    BHSc Nutritional Medicine, International health - University Of Queensland

    Diploma In Dermal Science - AACDS

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