Should You Take NMN and Resveratrol Together?

Should You Take NMN and Resveratrol Together?

Could this combination be the anti-aging breakthrough you've been searching for? In the quest for enhanced health and longevity, many are turning to NMN (Nicotinamide Mononucleotide) and Resveratrol, two supplements renowned for their anti-aging properties. 

This raises a couple of questions: What is it about these two? And does combining these two compounds amplify their health benefits? Discover NMN and Resveratrol and whether taking them together is the key to a more youthful life. 

Understanding NMN and Resveratrol

NMN, a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), is vital in cellular energy production and numerous crucial cellular processes. NAD+ levels naturally decline as we age, leading to age-related physiological changes. Supplementing with NMN is thought to enhance NAD+ levels, potentially slowing aspects of the aging process (R). 

Resveratrol, a natural compound found in red wine, berries, and peanuts, is celebrated for its antioxidant properties. It's believed to activate genes related to longevity and offer protection against age-related diseases, making it a complementary ally to NMN in the quest for sustained youth and health (R).

Do You Need to Take Resveratrol with NMN?

Combining NMN and Resveratrol is a powerful duo for anti-aging. But do you “need” to take Resveratrol and NMN together? The answer lies in understanding their mechanisms of action.

NMN boosts NAD+ levels, which are crucial for energy metabolism and cellular health. Resveratrol, on the other hand, activates SIRT1, a gene associated with longevity. Interestingly, SIRT1 requires NAD+ to function effectively. This interplay suggests that taking NMN could enhance the effectiveness of Resveratrol by ensuring adequate NAD+ levels for SIRT1 activation (R).

Moreover, studies have shown that combining these two compounds can produce synergistic effects. For instance, they may improve mitochondrial function, enhance energy metabolism, and provide better protection against oxidative stress than when taken individually (R).

Potential Benefits of Taking NMN and Resveratrol Together

Combining NMN and Resveratrol could offer multiple health benefits. Together, they may enhance longevity by activating longevity genes and improving cellular health, as evidenced in animal studies. 

They also can improve metabolic and cardiovascular health, which is crucial in combating aging and related diseases. Additionally, this combination might provide neuroprotective benefits, helping to guard against cognitive decline and neurodegenerative diseases. 

Lastly, by boosting cellular energy production, NMN and Resveratrol could increase overall energy levels and reduce fatigue, contributing to a heightened sense of vitality (R).

What the Research Tells Us About NMN and Resveratrol 

Recent studies shed light on the potential benefits of these two compounds when used together, contributing to anti-aging research.

  1. Enhanced NAD+ Levels: A study revealed that combining NMN with Resveratrol significantly increased NAD+ levels in mice's heart and muscle tissue, compared to NMN alone. This suggests a synergistic effect of NMN and Resveratrol in boosting NAD+ levels, which is critical for energy metabolism and cellular health (R).

  1. Cardiovascular Health: Resveratrol has demonstrated potential in improving cardiovascular function. For example, a study discussed the cardioprotective effects of Resveratrol, including its antioxidant and anti-inflammatory properties (R). 

  1. Metabolic Health: A study in Science Journal found that NMN supplementation improved insulin sensitivity in muscle in a study involving prediabetic women, highlighting its potential role in metabolic health (R).

  1. Neuroprotective Effects: One study indicated that Resveratrol activates the SIRT1/PGC-1 pathway, improving cognitive function after traumatic brain injury (R). This neuroprotective effect, combined with NMN's potential in enhancing cellular energy production, could offer a synergistic approach to protecting against neurodegenerative diseases and cognitive decline associated with aging.

  1. Anti-Inflammatory and Antioxidant Actions: Resveratrol's anti-inflammatory and antioxidant properties suggest its role in mitigating oxidative stress and inflammation, which are key factors in aging (R). When combined with NMN, which improves NAD+ levels, there's potential for enhanced protection against age-related oxidative damage.


In summary, combining NMN and Resveratrol may amplify their respective anti-aging benefits, presenting a synergistic strategy for enhancing overall well-being and extending lifespan. If you'd like to explore further information regarding the advantages of these supplements, consider exploring AgeMates NMN and Resveratrol.

As always, consulting with a healthcare professional before starting any new supplement regimen is advisable.

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Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

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