Can I Take NMN and NR on an Empty Stomach?

NMN empty stomach

Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) have become popular amongst those looking to boost their energy, improve overall well-being, and potentially slow aging. With rising popularity, questions have emerged about the best way to take NMN and NR, particularly if they are effective on an empty stomach.

A Basic Understanding of NMN and NR

Both NMN and NR are precursors to Nicotinamide Adenine Dinucleotide (NAD+), an essential molecule found in every living cell. NAD+ is crucial for processes such as energy production, DNA repair, and maintaining healthy circadian rhythms. However, NAD+ levels naturally decrease with age, which is linked to various age-related conditions. This decline has led to a focus on NMN and NR supplementation as potential anti-aging strategies.

Should I Take NMN and NR on an Empty Stomach?

There is ongoing debate about whether NMN and NR should be taken on an empty stomach to maximise their absorption and effectiveness. Research suggests that taking these supplements without food may be beneficial due to their water-soluble nature, which allows for absorption without the need for fats (R).


Some studies indicate that taking NMN and NR before meals may protect them from breakdown by stomach acid, thus facilitating more effective metabolism in the liver and quicker absorption in the small intestine. However, the effectiveness can vary based on individual health objectives and the specific supplement's formulation (R).

Learn more about some of the benefits of taking NMN when fasting.

Can I Take NMN and NR with Food? 

Yes, it is also possible to take NMN and NR with food, which might be a preferable option for those who experience gastrointestinal discomfort from supplements on an empty stomach. Consuming these compounds with meals may mitigate stomach irritation, particularly for individuals with sensitive digestive systems.

Additionally, integrating supplement intake with regular meal routines can enhance adherence to consistent supplementation.



While research leans towards taking NMN and NR on an empty stomach for optimal absorption, personal health considerations and experiences may lead some individuals to prefer taking them with food. It is vital to consult healthcare professionals to tailor the supplementation strategy to your unique health needs and goals.

Reading next

Body fat percentage
Bryan Johnson Longevity

Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

Daily Longevity Blend

A complete daily longevity routine with 18 ingredients, perfectly dosed and in their most bioavailable forms. Our all-in-one blend condenses the latest longevity research into one scoop.