Does NMN Increase Testosterone

Does NMN Increase Testosterone

In the realm of dietary supplements, Nicotinamide Mononucleotide (NMN) has emerged as a subject of significant interest due to its potential health benefits.

Among these potential advantages, early studies have hinted at a possible connection between NMN intake and amplified testosterone levels in men.

This article explores the scientific underpinnings linking NMN and answers the question - does NMN increase testosterone?

Deciphering NMN's Role in Testosterone Production

NMN is an essential precursor in the synthesis of nicotinamide adenine dinucleotide (NAD+), a crucial molecule involved in various cellular processes, including energy metabolism and DNA repair.

While there's ongoing research on NMN's broader impacts, its direct role in testosterone production specifically remains an area of interest (R).

Some studies suggest that NAD+ precursors, including NMN, may indirectly impact testosterone levels. Testosterone synthesis requires various enzymatic reactions, and NAD+ serves as a coenzyme for some of these enzymes involved in hormone production (R).

However, the exact mechanisms by which NMN influences testosterone levels aren't fully elucidated. It's believed that by supporting NAD+ production, NMN might indirectly contribute to maintaining cellular health, potentially affecting hormone balance, including testosterone production.

Scientific Studies: Unveiling the NMN and Testosterone Connection

NMN, has emerged as a prospective candidate for potentially enhancing testosterone levels in men.

There is ongoing research investigating the potential connection between NMN and testosterone levels.

Several scientific studies have delved into this area to uncover the relationship between NMN supplementation and changes in hormone levels, particularly testosterone.

A study conducted over 12 weeks unveiled that men consistently supplementing with NMN experienced a remarkable improvement in muscle function. Which some hypothesise may be linked to testosterone (R).

A recent study administered oral NMN doses daily over three months, significantly increasing overall serum testosterone and free or bioavailable forms. This signals an enhancement in overall hormonal equilibrium due to NMN supplementation (R).

Despite these promising findings, additional research is pivotal to authenticate NMN's influence on testosterone.

The Role of Tongkat Ali Root Extract and NMN in Counteracting Aging

In parallel with NMN, Tongkat Ali root extract (Eurycoma longifolia) has displayed anti-inflammatory properties potentially counteracting manifestations associated with ageing.

Persistent inflammation significantly contributes to age-linked illnesses, and both Tongkat Ali and NMN are believed to mitigate this by reducing inflammatory markers in the body.

Studies conducted on older adults supplemented with Tongkat Ali indicated diminished fatigue symptoms and elevated total and free testosterone levels, indicating an enriched quality of life akin to the effects observed with NMN supplementation (R, R).

Further Health Benefits of NMN Intake

Managing Blood Sugar Levels with NMN: Studies suggest substantial NMN intake could lower fasting glucose levels by up to 50%. This suggests potential advantages for individuals with type-2 diabetes or those vulnerable due to elevated fasting glucose levels.

Additionally, NMN has shown improvements in insulin sensitivity, a pivotal factor in staving off type-2 diabetes (R). Improved insulin sensitivity can positively affect hormone regulation, potentially influencing testosterone levels

Enhancing Metabolic Conditions: Studies showcasing NMN's potential to alleviate symptoms related to metabolic syndrome could indirectly influence testosterone levels

Studies involving mice indicated diminished indications of metabolic syndrome following oral NMN administration, showcasing hope for potential human benefits (R).

Anti-Inflammatory Effects: NMN has demonstrated anti-inflammatory attributes that could assist in weight management and overall well-being and might have implications for hormonal balance, potentially impacting testosterone levels.

Research involving older adults supplemented with NMN revealed reduced fatigue symptoms and elevated testosterone levels, signifying an ameliorated quality of life (R).

Connecting NMN's Anti-Aging Attributes to Testosterone Benefits

NMN's potential anti-aging attributes, primarily associated with increased Nicotinamide Adenine Dinucleotide (NAD+) levels, are noteworthy in the context of hormonal health, including testosterone levels.

As individuals age, NAD+ levels naturally decline, contributing to mitochondrial dysfunction—a factor strongly associated with aging manifestations and hormonal imbalances, including changes in testosterone levels (R).

Studies suggest that NMN supplementation could counteract this decline by elevating NAD+ levels, thereby enhancing mitochondrial health and cellular energy production. Improved mitochondrial function has been linked to hormonal balance, potentially influencing testosterone levels positively (R).

Consequently, preserving youthful cell function through NMN's effects on NAD+ levels might have implications for hormonal health, including testosterone regulation, offering insights into the broader impacts of NMN on the aging process.

Correlating NAD+ Levels to Age-Related Diseases Cognitive Health and Testosterone

The correlation between NMN's impact on NAD+ levels and its potential benefits for age-related illnesses and cognitive functions might indirectly influence testosterone levels (R).

Lower NAD+ levels have been associated with the progression of neurodegenerative conditions, suggesting NMN supplementation as a protective measure against such ailments (R).

As these conditions often have complex interactions with hormonal imbalances, including testosterone levels, the potential protective role of NMN in neurodegenerative disorders might have implications for hormonal health (R).

Moreover, the amplified cellular energy production resulting from heightened NAD+ levels could potentially impact physical vitality and cognitive functions.

Studies demonstrating improved cognitive capabilities in older mice due to NMN supplementation offer insights into potential cognitive advantages (R).

While limited in human studies, these findings hint at NMN's broader impact beyond physical health, potentially influencing hormonal balance and testosterone levels.

Bioavailability and Administration Methods for NMN

NMN's bioavailability, indicating how much is absorbed into the bloodstream and utilised by the body, fluctuates depending on the mode of administration.

Oral supplements are a convenient option. Intravenous infusions present challenges like cost and convenience.

Further investigation is imperative to ascertain optimal administration routes across a broader demographic spectrum, possibly exploring diverse dosage forms and frequencies for maximal efficacy.

Long-Term Studies and Future Research

Mentioning the necessity for more extended studies to understand the sustained effects of NMN on testosterone and overall health would emphasise the need for comprehensive research.

Highlighting ongoing or forthcoming clinical trials involving NMN supplementation in human subjects could offer insights into the current state of scientific inquiry.


In conclusion, while early studies present promising glimpses into NMN's potential impact on testosterone, continued research, extended trials, and a deeper understanding of NMN's mechanisms are pivotal to unravelling its full potential in influencing hormonal health and overall well-being.

As with any dietary supplement or medication, it is vital to consult a healthcare professional before commencing any supplement regimen, particularly if managing existing medical conditions or undergoing prescription medication.

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Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

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