How To Take NMN Powder

How To Take NMN Powder

Amidst the evolving research and growing interest in NMN (Nicotinamide Mononucleotide), we aim to clarify how NMN can be effectively incorporated into your wellness routine.


Can You Take NMN Orally? Or Only Sublingually?

In initial studies, NMN was administered to mice through direct injections into the peritoneal (abdominal) cavity. This led to a misconception among many that NMN cannot be taken orally.


NMN can be taken orally. In fact, oral consumption is one of the most common and convenient ways to take NMN supplements. When taken orally, AgeMate's NMN is available in the form of a capsule or powder, which can be mixed with water or another beverage.


Sublingual administration, where the substance is placed under the tongue for absorption, is another method that is sometimes used for NMN. The idea behind sublingual intake is that it may offer more direct absorption into the bloodstream, potentially bypassing the digestive system where some degradation of NMN could occur.


Do I Take NMN With or Without a Food?


When taking NMN (Nicotinamide Mononucleotide), you have the option to take it with or without food:

With Food:
1. Enhanced Absorption: Taking NMN with a fat-containing meal may improve absorption.
2. Reduced Gastrointestinal Discomfort: Helpful if you have a sensitive stomach.

Without Food:
1. Faster Absorption: An empty stomach might lead to quicker absorption.
2. Convenience: Some find it easier to take supplements on an empty stomach.

Ultimately, the choice depends on your personal tolerance and convenience.


Can Our Cells Absorb NMN?


It was also previously believed that cells could not directly absorb NMN. Recent studies indicate that NMN transporters do exist in the cell membrane, enabling direct uptake of NMN. Researchers also think it's highly probable that humans possess several other types of NMN transporters (R, R).


Importance of Hydration


Given that NMN is a water-soluble compound, maintaining adequate hydration is crucial. Drinking sufficient water throughout the day can support the body’s ability to process and utilise NMN effectively.


Timing for Optimal Results


Research on the best time to consume NMN is ongoing. One study, detailed in the article "How long does it take for NMN to start working," suggests afternoon consumption with a meal as the most effective timing (R). However, it's important to approach this advice with flexibility, as conclusive research on the ideal timing is still evolving.


Dr. David Sinclair’s NMN Routine


Dr. David Sinclair, a prominent aging researcher and co-founder of Life Biosciences, shared his personal NMN intake routine. Known for his extensive work in aging research, Sinclair consumes 250mg of NMN orally every morning before breakfast.


He dissolves the powder in water, drinks it swiftly, and then proceeds with his normal breakfast routine. Additionally, he takes a second 250mg dose before dinner.


Sinclair’s approach, which involves taking NMN twice daily, is based on the premise that our bodies are in a constant state of cellular breakdown and repair. He theorises that consuming NMN twice a day provides a steady supply of the compound, potentially enhancing its effectiveness in supporting cellular health.



While personal routines like Dr. Sinclair’s offer insight, it’s essential to consider that individual responses to NMN can vary. Ongoing research continues to shed light on the most effective ways to use NMN, and staying informed about new findings is key to optimising its use.


Always consult with a healthcare professional before beginning any new supplement regimen.

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Written By Natasha Jordan

BHSc Nutritional Medicine, International health - University Of Queensland

Diploma In Dermal Science - AACDS

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