Summary
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What is Choline (from Choline Bitartrate)?
Choline bitartrate is a form of choline, an essential nutrient supporting several vital bodily functions. It is known for its high bioavailability, making it an efficient way to supplement dietary choline intake.
Choline is critical for brain health, supporting neurotransmitter synthesis and cell membrane integrity, and plays a key role in lipid metabolism and liver function.
Choline (from Choline Bitartrate) Impact on Health, Aging and Longevity
Choline deficiency is linked to liver diseases such as fatty liver disease (steatosis) and potentially more severe liver damage. The consumption of choline-rich foods or supplements is essential for maintaining liver health and preventing these conditions. Choline's role in fat metabolism is critical, as it helps prevent the accumulation of fat in the liver, a key factor in nonalcoholic fatty liver disease (NAFLD) (R).
Choline is crucial for brain health, with high intake during gestation and early postnatal development improving cognitive function, preventing age-related memory decline, and protecting against neuropathological changes associated with Alzheimer's disease and neurological damage (R).
These effects are correlated with modifications in histone and DNA methylation in the brain, suggesting a potential epigenomic mechanism of action (R).
Chronic choline supplementation has been shown to improve cognitive and motor performance by modulating oxidative and neurochemical status in rats. This suggests that choline intake could also benefit human neurological health and potentially prevent cognitive and motor disorders later in life (R).
Aerobic exercise impacts cerebral metabolism and grey matter volume in older adults, and choline levels may play a role in these changes. However, the specific effects of choline supplementation on brain metabolism and structure in the context of exercise and aging remain to be fully elucidated (R).
