Key Takeaways
- NMN/NR, resveratrol, and spermidine act on fundamental cellular pathways, such as NAD+ biosynthesis, sirtuin activation, and autophagy, to slow ageing, enhance skin elasticity, and improve overall cellular health.
- A diet rich in antioxidants, collagen precursors, and anti-inflammatory compounds complements supplementation, creating an optimal environment for skin renewal and longevity.
- The Longevity Blend delivers a targeted combination of NMN/NR, spermidine, and synergistic nutrients to combat the biochemical drivers of ageing and promote youthful skin.
Your skin’s youthful appearance depends on the ability of your cells to generate ATP, repair DNA damage, and regulate inflammatory pathways. Key nutrients like NMN, NR, resveratrol, and spermidine target these processes, supporting cellular health at a molecular level.
NMN and NR: The Cellular Powerhouses
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are precursors to nicotinamide adenine dinucleotide (NAD+), a coenzyme required for over 500 enzymatic reactions, including DNA repair, mitochondrial energy production, and sirtuin activation (R).
How NMN and NR Fight Ageing
NAD+ Decline: Ageing decreases NAD+ levels, impairing mitochondrial function and sirtuin activity. This leads to reduced ATP production, increased oxidative stress, and slower cellular repair (R).
Supplementation: NMN and NR bypass rate-limiting steps in NAD+ biosynthesis, rapidly replenishing NAD+ pools in tissues, including the skin (R).
Sirtuin Activation: Sirtuins, NAD+-dependent enzymes, regulate gene expression for collagen synthesis, oxidative stress resistance, and inflammation control. Elevated NAD+ levels from NMN/NR supplementation enhance sirtuin activity, restoring cellular homeostasis (R).
DNA Repair: NAD+ is critical for activating PARPs (poly-ADP-ribose polymerases), enzymes that repair DNA breaks caused by UV radiation and environmental stressors (R).
Scientific Evidence:
- A study published in Cell Metabolism (2018) demonstrated that NMN supplementation improved mitochondrial function and delayed age-related decline in mouse models.
- Research in Nature Communications (2020) suggest NAD+ precursors like Nicotinamide Riboside (NR) reduce oxidative stress and support cellular health
Explore more human clinical trials here.
Resveratrol: Nature’s Ageing Shield
Resveratrol, a polyphenol, modulates cellular pathways involved in oxidative stress, inflammation, and mitochondrial biogenesis.
How Resveratrol Protects Your Skin
Sirtuin Modulation: Resveratrol directly activates sirtuins, particularly SIRT1, enhancing DNA repair and promoting collagen preservation (R).
Antioxidant Activity: Resveratrol neutralizes reactive oxygen species (ROS), preventing oxidative damage to lipids, proteins, and DNA in skin cells (R).
UV Protection: Studies show that resveratrol reduces UV-induced damage by increasing the expression of endogenous antioxidants like glutathione peroxidase (R).
Scientific Evidence:
- A 2019 review in Antioxidants highlighted resveratrol’s ability to mitigate photodamage and improve skin elasticity (R).
- A 2021 study on a 2% resveratrol emulsion demonstrated anti-aging benefits, including improved skin elasticity and reduced skin roughness after 8 weeks (R).
Spermidine: A Catalyst for Skin Renewal
Spermidine, a polyamine found in high concentrations in healthy cells, triggers autophagy, a vital cellular recycling process.
Spermidine’s Role in Youthful Ageing
Autophagy Activation: Spermidine enhances the degradation of damaged organelles and proteins, reducing cellular senescence markers like p16 and p21 (R).
Collagen Protection: By mitigating inflammation and oxidative damage, spermidine preserves extracellular matrix components, maintaining skin elasticity (R).
Epigenetic Influence: Spermidine modulates histone acetylation, promoting gene expression patterns associated with healthy ageing (R).
Scientific Evidence:
- A study in GeroScience (2020) found that long-term spermidine treatment improved healthspan in rats, including effects on neuroinflammation and exploratory behaviour (R).
- A study in Cell Communication and Signaling (2020) found that spermidine accelerated wound healing by enhancing autophagy and inflammatory response regulation, indicating potential skin benefits (R).
TMG: Protecting Your Skin from Within
Trimethylglycine (TMG), derived from beetroot, is a methyl donor essential for DNA and protein stability.
TMG’s Role in Skin Health
Methylation Support: TMG supports methylation of DNA, which is critical for maintaining the integrity of genetic material and regulating inflammatory pathways (R).
Hydration: TMG acts as an osmolyte, stabilizing cell membranes and ensuring hydration under stress (R).
Homocysteine Reduction: Elevated homocysteine levels are linked to inflammation and oxidative stress. TMG converts homocysteine to methionine, reducing its damaging effects (R).
Scientific Evidence:
This study highlights the anti-inflammatory effects of betaine (TMG), showing its role in inhibiting nuclear factor-κB activity, reducing oxidative stress, and mitigating inflammation across various diseases such as obesity, diabetes, and Alzheimer’s disease (R).
Berberine: The Anti-Inflammatory Superhero
Berberine, an alkaloid extracted from plants, regulates AMPK (AMP-activated protein kinase), a key enzyme in energy metabolism and inflammation (R).
How Berberine Supports Youthful Skin
AMPK Activation: Berberine enhances mitochondrial efficiency, supporting ATP production for skin cell repair (R).
Anti-Inflammatory Effects: By suppressing NF-κB, berberine reduces cytokine production, preventing chronic inflammation (R).
Glucose Metabolism: Berberine improves insulin sensitivity, reducing advanced glycation end products (AGEs) that damage collagen fibers (R).
Scientific Evidence:
A study highlighted berberine’s ability to inhibit pro-inflammatory cytokines, such as IL-6 and CCL11, by modulating the STAT6 pathway in human epithelial cells (R).
Creating a Holistic Anti-Ageing Routine
To optimise skin health and longevity, integrate these steps into your routine:
- Targeted Supplements: Use NMN/NR, spermidine, and resveratrol to address ageing at the cellular level.
- Nutrient-Rich Diet: Include antioxidants (e.g., vitamin C), polyphenols, and omega-3s.
- Skincare Regimen: Apply SPF daily and use hydration-focused products with hyaluronic acid.
- Lifestyle Factors: Stay active, prioritise sleep, and manage stress to reduce systemic inflammation.
NMN/NR, resveratrol, and spermidine work together like a dream team for your cells. They support key processes like NAD+ production, sirtuin activation, and autophagy – the cellular clean-up crew. The result? Slower ageing, firmer, more elastic skin, and better overall cellular health.
Interested in learning more ways to keep you looking younger than your age? Read our blog: Foods That Keep you Looking Youthful.
