Dr. David Sinclair is an Australian-American biologist and professor known for his research in aging and longevity.
He was a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.
Dr. Sinclair is particularly well-known for his work on genes and molecules involved in regulating lifespan, including the SIRT1 gene and its associated proteins, which regulate cellular processes such as DNA repair, metabolism, and gene expression.
He has written books and published numerous scientific articles on aging, including "Lifespan: Why We Age—and Why We Don't Have To," which discusses strategies for extending a healthy human lifespan (R).
David Sinclair knows what he's talking about regarding supplements, as he's considered one of the world's top scientists regarding aging. Let’s explore some insights into Dr David Sinclair’s current longevity regime.
What is Dr. David Sinclair’s Supplement and Longevity Drug Stack?
Dr. David Sinclair has been associated with various dietary supplements and practices that he believes may promote longevity and overall health.
Although he doesn’t personally endorse any particular supplement, he suggests he follows a regime.
Nicotinamide Mononucleotide (NMN)
- Daily Dose: 1g in the morning (and possibly at night)
Dr. Sinclair has been a proponent of NMN. This molecule is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), which plays a role in various cellular processes, including energy metabolism and DNA repair.
NMN is a precursor to NAD+, offering DNA protection and repair, epigenome regulation, and metabolic benefits (R, R).
NMN has been shown to have many anti-aging benefits in animal studies (R, R, R, R).
Resveratrol
- Daily Dose: 1g in the morning
Resveratrol is a polyphenol found in foods like red grapes and red wine.
It has been associated with potential health benefits, and Dr. Sinclair's research has explored its role in mimicking the effects of calorie restriction and promoting longevity.
Dr. Sinclair believes in the synergy between resveratrol and NMN for DNA and epigenome protection.
Essentially, activating sirtuin genes, which safeguard our DNA and epigenome, requires a molecule such as resveratrol, while NMN is essential to provide energy to the sirtuins (R, R).
Vitamin D3
- Ideal Dose: 4000 to 5000 IU per day
Vitamin D is essential to various bodily functions, including bone health and immune system support.
Vitamin D has shown potential in extending lifespan and reducing the risk of aging-related diseases, including heart disease, type 2 diabetes, autoimmune diseases and Alzheimer’s disease. (R, R).
Vitamin K2
- Ideal Dose: 180 to 360 micrograms per day
Vitamin K is an essential nutrient that plays a role in blood clotting and overall bone, vascular, and mitochondrial health, especially when taking vitamin D (R).
Vitamin K supplements can vary based on individual needs, dietary habits, and health considerations. Dr. Sinclair has discussed the importance of vitamin K in various contexts.
Alpha Lipoic Acid (ALA)
- Recent status uncertain
Despite mixed findings on its effects on aging (R), ALA remains a potent antioxidant with potential benefits in cellular energy production, glucose regulation and neuroprotection (R, R).
While ALA shows promise in these areas, it's important to note that scientific evidence on its anti-aging effects is still emerging.
Coenzyme Q10 (CoQ10)
- Recent status uncertain
CoQ10 is a naturally occurring compound with antioxidant properties, and it plays a role in cellular energy production (R).
The evidence for CoQ10's impact on lifespan needs to be more conclusive (R). Previous sources indicated that Dr. Sinclair discussed his use of coenzyme Q10. However, in interviews conducted in 2022, there was no explicit mention of his supplementation with this specific product.
Spermidine
- 1 mg per day in the morning
Dr. Sinclair has discussed the potential benefits of spermidine in interviews and articles and mentioned that he includes spermidine in his supplement regimen.
Spermidine is a naturally occurring polyamine found in various foods, and it has been the subject of scientific investigation for its potential health benefits.
Some research has suggested that spermidine may have anti-aging and cellular health-promoting properties (R, R).
Quercetin and Fisetin
- 500 mg each, once per day, in the morning
Dr. Sinclair has mentioned the concept of senolytics, which are compounds that may help remove or rejuvenate senescent cells in the body.
Quercetin and fisetin are among the compounds investigated for their senolytic potential.
They are believed to have properties that could aid in clearing senescent cells associated with aging and age-related diseases (R).
TMG (trimethyl glycine or betaine)
- 500 mg to 1,000 mg per day
TMG, also known as betaine, is a naturally occurring compound found in various foods and has been studied for its potential health benefits, particularly in relation to methylation and homocysteine metabolism (R).
Low-Dose Aspirin
- Daily Dose: 83 mg
While a recent study raised doubts (R), aspirin still holds promise in reducing inflammation and the risk of heart attacks.
Low-dose aspirin is sometimes recommended for specific individuals, particularly those at risk for cardiovascular events, as it can help prevent blood clot formation (R).
However, its use is typically determined by individual health considerations and should be discussed with a healthcare provider.
Statin and Metformin
Statins and Metformin are prescription medications, so you must discuss the possible benefits and risks with your healthcare provider.
Dr. Sinclair's Approach to Nutrition
Dr. Sinclair adopts unique eating habits, including intermittent fasting and eating two meals daily.
He emphasises the importance of energy-boosting green tea and a diet rich in fibre-laden vegetables to optimise bodily functions.
Dr. Sinclair’s Approach to Exercise
Regular exercise is a cornerstone of Dr. Sinclair's health regimen. He combines low and high-intensity workouts, engages in weight lifting, and enjoys the multifaceted benefits of staying active, from improved energy levels to enhanced mental acuity.
Conclusion
Dr. David Sinclair, a luminary in the field of aging science, leads by example in his pursuit of a long and healthy life. While his supplement regimen is meticulously designed, he acknowledges the importance of a balanced diet and regular exercise.
As the science evolves, Dr. Sinclair remains open to adjusting his approach and encourages others to prioritise NMN supplements in their 30s.
His dedication to lifelong health serves as an inspiration for all who aspire to age gracefully and healthily.
It's important to stress that individuals should consult with a healthcare professional before incorporating any supplements or medications into one's regimen.
